UPS Cargo Plane Crashes After Takeoff in Louisville, Killing at Least 7A UPS cargo plane crash occurred on November 4, 2025, shortly after takeoff from Louisville Muhammad Ali International Airport in Kentucky, resulting in at least seven fatalities and multiple injuries. The McDonnell Douglas MD-11F aircraft, carrying three crew members, was en route to Daniel K. Inouye International Airport in Honolulu, Hawaii, when it crashed near the airport around 5:15 PM EST.Witnesses reported seeing the plane struggling to gain altitude, followed by a sharp descent and fiery crash that ignited fires and damaged nearby buildings, including a UPS supply warehouse. Emergency responders quickly arrived on the scene, battling intense flames fueled by the plane’s large jet fuel load.The crash also affected people on the ground, with at least four more fatalities and several injuries reported. Local authorities imposed a shelter-in-place order within a five-mile radius of the airport and temporarily closed the airfield, halting all flights. Kentucky Governor Andy Beshear and Louisville Mayor Craig Greenberg have expressed condolences and praised first responders.The National Transportation Safety Board (NTSB) and the Federal Aviation Administration (FAA) have launched investigations to determine the cause of the tragic accident. Louisville serves as a major hub for UPS, with its Worldport facility handling over 300 daily flights and millions of packages. The crash is one of the deadliest cargo plane incidents in recent U.S. history.Stay tuned for more updates on the UPS plane crash in Louisville.This light updates-optimized article includes key search terms such as "UPS cargo plane crash," "Louisville Muhammad Ali International Airport," "MD-11F aircraft," "fatalities and injuries," and "investigation," making it suitable for news websites and search engines while providing clear, factual information light updates.